Premium
TEMPERATURE AND BEHAVIOURAL RESPONSES INDUCED IN THE UNANAESTHETIZED CAT BY THE CENTRAL ADMINISTRATION OF RX72601, A NEW ANTICHOLINESTERASE
Author(s) -
METCALF G.,
MYERS R.D.,
REDGRAVE P.C.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07604.x
Subject(s) - forebrain , hyperthermia , midbrain , cerebral ventricle , lateral ventricles , neuroscience , anesthesia , pharmacology , medicine , central nervous system , chemistry , biology , anatomy
1 The central effects produced by a new anticholinesterase RX72601 injected into the cerebral ventricles or perfused within circumscribed forebrain structures have been investigated in the unanaesthetized cat. 2 When injected into the cerebral ventricles in doses of 1–10 μg, RX72601 produced a dose‐related hyperthermia together with behavioural and autonomic responses. 3 Experiments designed to localize the site or sites of these actions demonstrated that hyperthermia could be produced from several diencephalic sites but that the other effects were not normally produced from these same sites.