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PROSTAGLANDIN RELEASE FROM CAT AND DOG SPLEEN
Author(s) -
BEDWANI J.R.,
MILLAR G.C.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07597.x
Subject(s) - spleen , prostaglandin , prostaglandin f2alpha , endocrinology , cats , medicine , stimulation , endogeny , prostaglandin e2 , prostaglandin e , chemistry , saline , carnivora , biology
1 The output of prostaglandins from the spleens of cats and dogs was studied. Comparison is made between the results found in the two species. 2 The release of prostaglandins was investigated in isolated saline‐perfused spleens and in incubates of spleen slices. Release in response to nerve stimulation, and exposure to adrenaline or noradrenaline was compared with resting release. 3 A resting release of prostaglandins was found in the dog but not in the cat spleen. 4 Whereas stimulated dog spleens released microgram quantities of prostaglandins E 2 and F 2α , prostaglandin output from the cat spleen under similar conditions was undetectable or barely detectable. 5 The identity of the prostaglandins released from the dog spleen (prostaglandins E 2 and F 2α ) was confirmed by mass spectrometry. 6 The species difference in prostaglandin output from the spleen is discussed in relation to the hypothesis that endogenous prostaglandins modify the responses of this organ to nervous stimuli.