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THE EFFECTS OF HYPERCHOLESTEROLAEMIC PLASMA ON VASCULAR SENSITIVITY TO NORADRENALINE
Author(s) -
BLOOM D.,
McCALDEN T.A.,
ROSENDORFF C.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07587.x
Subject(s) - long term potentiation , medicine , endocrinology , chemistry , biology , receptor
1 The pressor responses to injected noradrenaline (NA) of 42 isolated perfused femoral arteries of the rabbit were studied. 2 Potentiation of the responses was found when hypercholesterolaemic plasma was perfused through the arteries. No change was found with normal plasma. 3 Potentiation of the responses was found when isolated β‐lipoprotein in Krebs solution was perfused. No change was found with similar amounts of bovine albumen. 4 Pure cholesterol dissolved directly into normal plasma, and dissolved via propanol into Krebs solution or plasma caused no potentiation. Propanol alone in Krebs or plasma had no effect. 5 Potentiation was caused by a decreased equilibrium coefficient ( K eq ) for the NA‐adrenoceptor interaction and an increased maximal pressor response ( R max ). 6 It is concluded that cholesterol carried on its apoprotein is capable of potentiating the pressor effects of noradrenaline.