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In vitro INHIBITION OF BRAIN MITOCHONDRIAL MONOAMINE OXIDASE BY 6‐HYDROXYDOPAMINE
Author(s) -
YOUDIM M.B.H.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07583.x
Subject(s) - hydroxydopamine , monoamine oxidase , in vitro , chemistry , neuroscience , monoamine oxidase b , pharmacology , mitochondrion , biology , biochemistry , enzyme , dopamine , dopaminergic
6‐Hydroxydopamine (6‐OHDA) inhibits rat brain mitochondrial monoamine oxidase (MAO) when kynuramine or dopamine are used as substrates. The effect is competitive and reversible giving Ki values of 74 and 176 μM with the respective substrates. At high concentrations (5 mM) of each substrate, inhibition of MAO was not observed.