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DEPOLARIZING EFFECTS OF THE IONOPHORES X‐537A AND A23187 AND THEIR RELEVANCE TO SECRETION
Author(s) -
COCHRANE D.E.,
DOUGLAS W.W.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07582.x
Subject(s) - depolarization , ionophore , calcium , membrane potential , chemistry , secretion , biophysics , medicine , biology , biochemistry
The ionophore X‐537A depolarized frog skeletal muscle fibres about 10 mV in 10 min and a further 30 mV or so over the next 50 minutes. With A23187, depolarization was relatively feeble and delayed in onset but was hastened when calcium was removed from the bathing medium. The results support conjecture that some functional responses to these ionophores are attributable, in part, to depolarization.