Premium
COMPARATIVE BIOASSAY OF PROSTAGLANDIN E 2 AND ITS THREE PULMONARY METABOLITES
Author(s) -
CRUTCHLEY D.J.,
PIPER PRISCILLA J.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07581.x
Subject(s) - prostaglandin e2 , prostaglandin , guinea pig , bioassay , ileum , uterus , smooth muscle , aorta , pulmonary artery , stomach , medicine , biology , endocrinology , pharmacology , chemistry , genetics
The relative potencies of prostaglandin E 2 and its metabolites 15‐keto PGE 2 , 13,14‐dihydro‐15‐keto‐PGE 2 and 13,14, dihydro‐PGE 2 were investigated on isolated smooth muscle preparations. These were rat stomach strip, colon and uterus, chick rectum, guinea‐pig ileum, trachea and pulmonary artery and rabbit aorta and pulmonary artery. 15‐keto PGE 2 was equiactive or 1–1.8 times more potent than prostaglandin E 2 in relaxing guinea‐pig trachea but otherwise the three metabolites were less active than prostaglandin E 2 on all preparations.