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THE ACTIONS OF FLUPENTHIXOL UPON 5‐HYDROXYTRYPTAMINE‐INDUCED AGGREGATION AND THE UPTAKE OF 5‐HYDROXYTRYPTAMINE AND DOPAMINE BY HUMAN BLOOD PLATELETS
Author(s) -
BOULLIN D.J.,
GRIMES R.P.J.,
ORR M.W.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07432.x
Subject(s) - dopamine , chemistry , platelet , serotonin , platelet aggregation , pharmacology , alpha (finance) , beta (programming language) , biochemistry , medicine , biology , receptor , construct validity , nursing , computer science , patient satisfaction , programming language
The effects of the α‐ and β‐isomers of flupenthixol on 5‐hydroxytryptamine (5‐HT)‐induced platelet aggregation and on 5‐HT and dopamine uptake were investigated. α‐Flupenthixol was 185 times more potent than the β‐isomer as an inhibitor of platelet aggregation. In contrast both isomers were equipotent as inhibitors of uptake of 5‐HT and dopamine. The data suggest that 5‐HT‐induced aggregation and uptake are separate processes.