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THE EFFECTS OF LITHIUM IONS ON THE ANTIDIURETIC ACTION OF VASOPRESSIN IN THE RAT
Author(s) -
JENNER F.A.,
MACNEIL SHEILA
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07428.x
Subject(s) - vasopressin , antidiuretic , lithium (medication) , endocrinology , medicine , action (physics) , chemistry , physics , quantum mechanics
1 The effect of intravenous infusion of lithium, 2.56 μmol/min on the antidiuretic responses to antidiuretic hormone (ADH), adenosine triphosphate (ATP), 3′‐5′ adenosine cyclic monophosphate (cyclic AMP) and theophylline was studied in water‐loaded, alcohol‐anaesthetized rats. 2 Lithium reversibly inhibits the antidiuretic response to all concentrations of ADH, depressing the maximum response but not changing the amount required for half maximal response. 3 The rate of increase of serum lithium relates more clearly to the inhibitory effect than does the serum concentration. 4 Sodium concentrations in the renal papilla seem to fall when serum lithium levels are rising. 5 Lithium inhibits the antidiuretic response to ATP and cyclic AMP but does not inhibit the response to theophylline.