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STUDIES ON THE BEHAVIOURAL PHARMACOLOGY OF A CYCLIC ANALOGUE OF DOPAMINE FOLLOWING ITS INJECTION INTO THE BRAINS OF CONSCIOUS RATS
Author(s) -
ELKHAWAD A.O.,
WOODRUFF G.N.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07416.x
Subject(s) - nucleus accumbens , pimozide , dopamine , stimulation , caudate nucleus , chemistry , stimulant , endocrinology , medicine , haloperidol , pharmacology
1 The cyclic analogue of dopamine, 2‐amino‐6,7‐dihydroxy‐1,2,3,4‐tetrahydronaphthalene (ADTN) was injected into the lateral ventricle or bilaterally into the nucleus accumbens or caudate nucleus of conscious rats and its effect on locomotor activity was investigated. 2 When given intraventricularly, ADTN produced some stereotyped responses which were followed by a strong and long lasting stimulation of locomotor activity. When administered bilaterally into the nucleus accumbens a similar stimulation of locomotor activity was observed. ADTN had no effect on locomotor activity when injected bilaterally into the caudate nucleus. 3 The ADTN‐induced locomotor stimulation following its intraventricular injection was completely abolished by a low dose of pimozide (0.01 mg/kg, i.p.) or haloperidol (0.5 mg/kg, i.p.). Pimozide (1 mg/kg, i.p.) given 30 min before ADTN injected bilaterally into the nucleus accumbens completely blocked locomotor stimulation. 4 Unilateral injections of ADTN (5 μg) into the nucleus accumbens caused locomotor stimulation but no turning. 5 Bilateral injections into the nucleus accumbens of 2‐amino‐6,7‐dimethoxy‐1,2,3,4‐tetrahydronaphthalene or 0.9% w/v NaCl solution had no effect on locomotor activity. 6 It is concluded that the central stimulant action of ADTN is due to an effect on the dopamine receptors in the nucleus accumbens.