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MODULATION BY ACETYLCHOLINE OF ADRENERGIC TRANSMISSION IN THE RABBIT EAR ARTERY
Author(s) -
ALLEN G.S.,
GLOVER A.B.,
McCULLOCH M.W.,
RAND M.J.,
STORY D.F.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07408.x
Subject(s) - hexamethonium , acetylcholine , atropine , medicine , endocrinology , stimulation , adrenergic , human ear , chemistry , inhibitory postsynaptic potential , biology , receptor , physics , acoustics
1 Low concentrations of acetylcholine (4 × 10 −11 and 1 × 10 −10 M) increase the vasoconstrictor response of the isolated ear artery of the rabbit to stimulation of the periarterial sympathetic nerves. Higher concentrations (4 × 10 −8 M and greater) decrease the response. 2 Low concentrations of acetylcholine (1 × 10 −11 and 1 × 10 −10 M) increase the stimulation‐induced efflux of radioactivity from artery segments previously incubated with [ 3 H]‐noradrenaline. Higher concentrations (3 × 10 −8 M and greater) decrease the efflux. 3 Neither atropine nor hexamethonium affects the facilitatory action of low concentrations of acetylcholine on adrenergic transmission in the rabbit ear artery. 4 Atropine antagonizes the inhibitory effect of higher concentrations of acetylcholine on adrenergic transmission.