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RENAL TUBULAR EXCRETION OF TRIETHYLCHOLINE (TEC) IN THE CHICKEN: ENHANCEMENT AND INHIBITION OF RENAL EXCRETION OF CHOLINE AND ACETYLCHOLINE BY TEC
Author(s) -
ACARA MARGARET,
KOWALSKI MARGARET,
RENNICK BARBARA,
HEMSWORTH B.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07407.x
Subject(s) - tec , choline , chemistry , excretion , kidney , endocrinology , medicine , acetylcholine , biochemistry , biology , ionosphere , physics , astronomy
1 [ 3 H]‐triethylcholine (TEC) was actively transported by the renal tubule of the chicken at a rate 85% that of simultaneously administered p ‐aminohippuric acid (PAH). 2 TEC was demonstrated to be transported by the organic cation transport system in the kidney through inhibition with quinine and the bio‐cation choline. 3 When the infusion of TEC was increased to 2 × 10 −6 mol kg −1 min −1 reaching the infused kidney, the transport of [ 3 H]‐TEC was inhibited, suggesting that an excretory transport maximum for TEC in the renal tubules had been reached. 4 The excretion of both choline and acetylcholine was enhanced by TEC loads as low as 1 × 10 −18 mol kg −1 min −1 . Enhancement continued as TEC infusion was increased up to approximately 1 × 10 −7 mol kg −1 min −1 at which point this enhancement was converted to inhibition. 5 Possible mechanisms for the biphasic effect of TEC on organic cation transport are discussed.