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A COMPARISON OF THE EFFECTS OF CYTOSINE ARABINOSIDE AND ADENINE ARABINOSIDE ON SOME ASPECTS OF BRAIN GROWTH AND DEVELOPMENT IN THE RAT
Author(s) -
ADLARD B.P.F.,
DOBBING J.,
SANDS JEAN
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07406.x
Subject(s) - offspring , cytosine , cerebellum , gestation , medicine , endocrinology , cytarabine , pregnancy , biology , pharmacology , chemotherapy , biochemistry , genetics , dna
1 Treatment of pregnant rats with cytosine arabinoside (ara‐C, 50 mg/kg, i.p.) at 14 days of gestation severely impaired both prenatal and postnatal whole brain growth in their offspring, although the cerebellum was relatively less affected than whole brain. 2 Rats treated at 5 days of age with ara‐C (250 mg/kg, i.p.) showed an impairment in growth of the cerebellum relative to the rest of the brain. 3 Adenine arabinoside (ara‐A) treatment, either prenatally or postnatally, had negligible effect on brain growth, even at doses considerably higher than those of ara‐C. 4 Adult rats, previously treated with ara‐C (50 mg/kg, i.p.) at 14 days of gestation, showed an impairment in discrimination learning when tested in a water T‐maze. 5 These results are discussed in relation to the proposed use of ara‐C or ara‐A as antiviral agents, particularly against intrauterine infection with cytomegalovirus.