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ACETYLCHOLINE‐SENSITIVE CELLS IN THE CAUDAL MEDULLA OF THE RAT: DISTRIBUTION, PHARMACOLOGY AND EFFECTS OF PENTOBARBITONE
Author(s) -
DUGGAN A.W.,
HEADLEY P.M.,
LODGE D.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07405.x
Subject(s) - acetylcholine , atropine , reticular formation , muscarinic antagonist , muscarinic acetylcholine receptor , stimulation , chemistry , medulla oblongata , antagonist , hypoglossal nucleus , medulla , cholinergic , neuroscience , medicine , endocrinology , nucleus , biology , central nervous system , biochemistry , receptor
1 The distribution of cholinoceptive and non‐cholinoceptive cells in various nuclei of the caudal medulla of the rat is described. 2 The nature of the responses of cells of the paramedian reticular nucleus and of the perihypoglossal nuclei to electrophoretically applied acetylcholine (ACh) was investigated. 3 In unanaesthetized decerebrate preparations ACh responses were usually of a ‘fast onset‐fast offset’ nature. Dihydro‐β‐erythroidine was a more effective antagonist than atropine. 4 In rats anaesthetized with barbiturate nearly all the ACh responses showed a slower onset and prolonged action. Atropine was the more effective antagonist. 5 The synaptic responses of cells of the paramedian reticular and perihypoglossal nuclei to stimulation of glossopharyngeal, superior laryngeal, lingual and hypoglossal nerves were investigated. It is concluded that ACh does not mediate the responses at the level of these nuclei.