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LOCAL ANAESTHETIC AND ANTIARRHYTHMIC PROPERTIES OF AN AMINOSTEROID: 3α‐DIMETHYL‐AMINO‐5α‐ANDROSTAN‐2β‐OL‐17‐ONE (ORG. NA13)
Author(s) -
BUCKETT W.R.,
MARWICK FIONA A.,
VARGAFTIG B.B.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07402.x
Subject(s) - aconitine , ouabain , toxicity , pharmacology , local anaesthetic , medicine , anesthesia , chemistry , organic chemistry , sodium
1 The aminosteroid Org. NA13 (3α‐dimethylamino‐5α‐androstan‐2β‐ol‐17‐one) was shown to be a more potent local anaesthetic than lignocaine in rats and guinea‐pigs. 2 Experimental arrhythmias induced in mice by chloroform, in rats by aconitine and in dogs by coronary artery ligation were corrected by Org. NA13 at doses from 10 to 50 mg/kg intravenously. 3 In contrast to lignocaine, other local anaesthetics and β‐adrenoceptor blocking drugs, Org. NA13 did not show any activity against the arrhythmias induced by ouabain in dogs. 4 The acute toxicity in whole animals and myocardial toxicity in the rabbit isolated atrium appeared to be less than that observed with lignocaine.