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INDOMETHACIN POTENTIATION OF THE RESPONSE OF THE RABBIT PORTAL VEIN TO ELECTRICAL STIMULATION: EFFECT OF STIMULUS FREQUENCY AND TRAIN LENGTH
Author(s) -
GREENBERG R.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07400.x
Subject(s) - long term potentiation , stimulation , stimulus (psychology) , portal vein , rabbit (cipher) , electric stimulation , chemistry , medicine , endocrinology , anesthesia , neuroscience , pharmacology , biology , psychology , receptor , mathematics , psychotherapist , statistics
The response of the rabbit isolated portal vein to electrical stimulation was potentiated by indomethacin (10 μg/ml). This potentiation was dependent upon frequency but independent of the number of pulses in a train. It is concluded that these results add further support for the idea that indomethacin increases the release of newly synthesized noradrenaline as a result of inhibition of prostaglandin synthesis.