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THE EFFECTS OF CATECHOLAMINES AND ADRENOCEPTOR BLOCKING DRUGS ON THE CANINE PERIPHERAL LYMPH FLOW
Author(s) -
MICHELI P.,
GLÄSSER A.H.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07386.x
Subject(s) - phenoxybenzamine , lymph , propranolol , medicine , lymphatic system , blood flow , vasoconstriction , isoprenaline , femoral artery , anesthesia , cardiology , pathology , stimulation
1 Blood flow through the femoral artery, lymph flow in a lymphatic vessel in the femoral triangle and metatarsal distal venous pressure were measured simultaneously in a canine moving hind limb. 2 Low intra‐arterial doses of adrenaline and noradrenaline increased lymph flow even in the presence of marked arterial vasoconstriction. In contrast, isoprenaline increased arterial blood flow without affecting lymph flow rate. 3 Phenoxybenzamine, dihydroergotoxine, and nicergoline did not inhibit the lymphatic flow increase induced by adrenaline at doses active on arterial or venous vascular alpha‐adrenoceptors. 4 Propranolol given intra‐arterially into animals pretreated with alpha‐adrenoceptor blocking agents restored the vasoconstrictor effect of adrenaline (reversal of adrenaline reversal).