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EFFECTS OF APOMORPHINE, ERGOCORNINE AND PIRIBEDIL ON AUDIOGENIC SEIZURES IN DBA/2 MICE
Author(s) -
ANLEZARK G.M.,
MELDRUM B.S.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07378.x
Subject(s) - apomorphine , pharmacology , tonic (physiology) , medicine , dopamine , chemistry , anesthesia , endocrinology , dopaminergic
Audiogenic seizures in DBA/2 mice have been studied after administration of drugs believed to act as dopamine agonists. Apomorphine at 0.4 mg/kg delays all phases of the response, the tonic phase is absent after 2.0 mg/kg; the clonic phase is abolished by 10 mg/kg. Ergocornine (0.5–8.0 mg/kg) produces effects on the latency and occurrence of seizure stages similar to those of apomorphine. Piribedil, ET 495 (4–100 mg/kg) is less potent; even after 100 mg/kg clonic and tonic phases occurred in 50% of the mice.