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CHOLINERGIC MECHANISMS IN CENTRAL THERMOREGULATION IN PIGEONS
Author(s) -
CHAWLA NARESH,
JOHRI M.B.L.,
SAXENA P.N.,
SINGHAL K.C.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07366.x
Subject(s) - carbachol , atropine , muscarinic acetylcholine receptor , hypothermia , acetylcholine , hyperthermia , thermoregulation , cholinergic , chemistry , endocrinology , medicine , oxotremorine , physostigmine , anesthesia , pharmacology , receptor
1 In unanaesthetized pigeons the effect on cloacal temperature was studied of acetylcholine (ACh), carbachol, atropine and (+)‐tubocurarine injected into a cannulated lateral cerebral ventricle. The experiments were carried out at an ambient temperature of 19–25°C. 2 ACh or carbachol injected intraventricularly produced hyperthermia, and in larger doses hyperthermia followed by hypothermia. These were central effects because they were not obtained when these drugs were injected in the same doses intravenously. 3 Atropine injected intraventricularly produced hypothermia which was greater and longer lasting than the hypothermia produced with the same dose of atropine injected intravenously. After the intraventricular injection of atropine the hyperthermic effects of ACh and of carbachol were abolished. 4 (+)‐Tubocurarine injected intraventricularly produced a long‐lasting hyperthermia in doses which had no effect on temperature when injected intravenously. After the intraventricular injection of tubocurarine the hypothermic effects of ACh and of carbachol were abolished. 5 It is concluded that the effects of ACh and carbachol imitate the effects of ACh released from cholinergic neurones in the central pathway involved in temperature regulation. The hypothermic effect of atropine is attributed to unmasking the activity of continuously released ACh acting on nicotinic receptors, and the hyperthermic effect of tubocurarine to unmasking the activity of continuously released ACh acting on muscarinic receptors.