Premium
THE EFFECTS OF BURIMAMIDE AND METIAMIDE ON BASAL GASTRIC FUNCTION IN THE CAT
Author(s) -
HARRIS D. W.,
SMY J.R.,
REED J.D.,
VENABLES C.W.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07361.x
Subject(s) - metiamide , pentagastrin , gastric acid , medicine , secretion , stomach , endocrinology , chemistry , gastric secretion , basal (medicine) , biology , antagonist , receptor , histamine h2 receptor , insulin
1 Burimamide injected intravenously in the anaesthetized or conscious cat produced significant increases in gastric acid secretion: in the anaesthetized cat it produced increased gastric mucosal blood flow. 2 Metiamide, in doses which inhibited pentagastrin‐stimulated acid secretion, produced no increase in gastric acid secretion in conscious animals, or gastric acid secretion or gastric mucosal blood flow in the anaesthetized cat. 3 Metiamide did not influence the amount of acid which diffused out of the stomach when instilled at pH values between 1.5 and 6.0. 4 The possible mode of action of burimamide in increasing basal gastric secretion is discussed.