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VARIATION IN ACTIVITY OF MONOAMINE METABOLIZING ENZYMES IN RAT LIVER DURING PREGNANCY
Author(s) -
PARVEZ SIMONE,
PARVEZ S.H.,
YOUDIM M.B.H.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07355.x
Subject(s) - monoamine oxidase , endocrinology , nialamide , medicine , catechol o methyl transferase , pregnancy , reserpine , tranylcypromine , iproniazid , enzyme assay , metabolism , enzyme , chemistry , biology , biochemistry , genetics , gene , allele
1 Catechol‐ O ‐methyltransferase (COMT) and monoamine oxidase (MAO) activities in rat liver were measured during pregnancy, parturition and postpartum. Compared with activity in non‐pregnant controls, both enzymes showed a significant decrease in activity which was most pronounced at day 18. 2 The metabolism of intravenously infused [ 3 H]‐adrenaline to [ 3 H]‐metanephrine and to [ 3 H]‐acidic metabolites was also significantly depressed during pregnancy but had returned to control values by the 21st day. 3 The effects of reserpine and/or nialamide on hepatic COMT and MAO were studied in control and 20‐day‐pregnant rats. Their action on COMT activity differed in the two groups. MAO was inhibited to a similar extent in these groups whether the drugs were given separately or in combination. 4 It seems possible that the changes in endocrine function which occur during pregnancy are responsible for the observed alterations in enzyme activity.