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USE OF THE LOGISTIC FUNCTION FOR THE CALCULATION OF DOSE‐RATIOS AND POTENCY RATIOS
Author(s) -
BARLOW R.B.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07341.x
Subject(s) - potency , function (biology) , medicine , statistics , chemistry , mathematics , pharmacology , biology , biochemistry , evolutionary biology , in vitro
1 Dose‐ratios and potency ratios, obtained with the guinea‐pig isolated ileum by calculating matching concentrations from a least‐squares fit using a logistic relationship between response and dose, differ from those obtained with the more usual assumption that response is a linear function of log dose over a limited range. 2 The differences are not due to the mathematical treatment of the results but arise from changes in sensitivity associated with the production of very high or very low responses. 3 With this preparation there is no advantage in avoiding the linear transformation and fitting the results to the complete dose‐response curve though this might not apply to results obtained from other tissues with less variable sensitivity.