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THE POSSIBLE OCCURRENCE OF ENDOGENOUS ANTI‐INFLAMMATORY SUBSTANCES IN THE BLOOD OF INJURED RATS
Author(s) -
ATKINSON D.C.,
HICKS R.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07333.x
Subject(s) - croton oil , sponge , inflammation , endogeny , anti inflammatory , pharmacology , lesion , chemistry , medicine , endocrinology , pathology , biology , botany
1 Using the carrageenin rat paw oedema test as an assay, an attempt has been made to confirm the presence of anti‐inflammatory activity in the blood of rats with a chronic inflammatory lesion induced by a polyester sponge, and to relate such activity to the systemic anti‐inflammatory effect exerted in situ by the lesion. In addition, plasma from rats given acetic acid intraperitoneally has been examined for anti‐inflammatory properties. 2 The activity of serum obtained from sponge‐bearing adrenalectomized Wistar rats did not differ significantly from that obtained from animals without implants. Furthermore, implanted sponges exerted no systemic anti‐inflammatory effect. 3 Similar experiments were performed in sponge‐bearing adrenalectomized Sprague‐Dawley rats, plasma instead of serum being examined for anti‐inflammatory activity. The plasma removed from such animals possessed no anti‐inflammatory activity, whilst implanted sponges exerted a small, yet significant, systemic inhibitory effect. 4 When the irritancy of sponge implants was augmented with croton oil, more marked systemic anti‐inflammatory effects were observed. However, the plasma obtained from rats injured in this manner exerted no anti‐inflammatory effect. 5 No anti‐inflammatory activity could be detected in plasma samples obtained from rats treated with doses of acetic acid capable of producing pronounced systemic anti‐inflammatory effects. 6 It was concluded that the induction of these inflammatory lesions in rats does not appear to lead to a detectable release of endogenous anti‐inflammatory substances into the circulation.