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A FURTHER INVESTIGATION INTO THE ENERGY DEPENDENCE OF ANGIOTENSIN II‐INDUCED CONTRACTIONS OF ISOLATED SMOOTH MUSCLE PREPARATIONS
Author(s) -
CROCKER ANN D.,
WILSON K.A.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07330.x
Subject(s) - endocrinology , medicine , angiotensin ii , dinitrophenol , uterus , acetylcholine , renin–angiotensin system , anaerobic exercise , contraction (grammar) , muscle contraction , chemistry , carbachol , biology , stimulation , physiology , blood pressure
1 The energy dependence of angiotensin and acetylcholine‐induced contractions of rat descending colon and uterus was investigated. 2 Differences were observed in the effect of anaerobic substrate depletion upon responses of colon and oestrous and dioestrous uterus. These were attributed to differences in the energy metabolism of the tissues and were correlated with differences in tissue levels of glycogen. 3 The preferential reduction of angiotensin responses of dioestrous uterus and descending colon when exposed to 2,4‐dinitrophenol, was evidence for an energy dependent stage in the angiotensin response distinct from the contraction process itself. 4 The absence of a preferential reduction of the angiotensin response of oestrous uterus when exposed to 2,4‐dinitrophenol appeared to be related to the ability of this tissue to generate ATP by anaerobic glycolysis. 5 It was concluded that the energy for the angiotensin response may be derived either anaerobically or aerobically, depending upon the tissue.