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THE EFFECT OF TRICYCLIC ANTI DEPRESSANTS ON CHOLINERGIC RESPONSES OF SINGLE CORTICAL NEURONES
Author(s) -
BEVAN P.,
BRADSHAW C.M.,
SZABADI E.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07326.x
Subject(s) - long term potentiation , desipramine , acetylcholine , cholinergic , atropine , imipramine , pharmacology , excitatory postsynaptic potential , neuroscience , chemistry , carbachol , inhibitory postsynaptic potential , antidepressant , medicine , psychology , receptor , hippocampus , stimulation , alternative medicine , pathology
1 The technique of microelectrophoresis was used in order to study the effects of tricyclic antidepressants on responses of single cortical neurones to acetylcholine. 2 Both potentiation and antagonism of excitatory responses to acetylcholine could be observed after a brief application of imipramine or desipramine. A higher dose of the antidepressant was required to evoke antagonism than to evoke potentiation. 3 Responses to carbachol were affected by desipramine similarly, suggesting that inhibition of Cholinesterase is not responsible for the potentiation of cholinergic responses. 4 A brief application of atropine also had a dual effect on responses to acetylcholine. 5 It is suggested that the potentiation of excitatory cholinergic responses by atropine and the antidepressants may be due to the blockade of masked inhibitory receptors.