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THE ACTION OF NITROGLYCERINE AND DIPYRIDAMOLE IN NORMAL AND ISCHAEMIC DOG HEART
Author(s) -
GRAYSON J.,
SCOTT C.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb07324.x
Subject(s) - dipyridamole , medicine , cardiology , vasodilation , anesthesia
1 Network and post‐network resistances were measured together with heat clearance and heat production in the myocardium. 2 Nitroglycerine dilated all resistance vessels but was twice as effective on network as compared with post‐network vessels. 3 Dipyridamole dilated network and post‐network vessels equally. 4 Nitroglycerine had no effect on heat clearance or heat production in ischaemic myocardium. 5 Dipyridamole increased heat clearance in normal but not in ischaemic myocardium. 6 Dipyridamole depressed heat production in normal and ischaemic myocardium. 7 That the clinical effectiveness of nitroglycerine does not depend entirely on its coronary vasodilator properties is confirmed. 8 It is suggested that the action of dipyridamole in depressing myocardial heat production may be due to an action on the efficiency of oxygen utilization during cardiac contraction.