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RESPONSE OF RAT LUNG TO HUMORAL MEDIATORS OF ANAPHYLAXIS AND ITS MODIFICATION BY DRUGS AND SENSITIZATION
Author(s) -
CHURCH M.K.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb06947.x
Subject(s) - bradykinin , acetylcholine , histamine , anaphylaxis , sensitization , pharmacology , guinea pig , bronchoconstriction , platelet activating factor , chemistry , endocrinology , medicine , immunology , allergy , asthma , receptor
1 The effects of humoral mediators of anaphylaxis on the bronchial function of the pithed rat have been assessed and compared with their effects in the guinea‐pig and man. 2 5‐Hydroxtryptamine, acetylcholine and bradykinin were bronchoconstrictor. Slow reacting substance in anaphylaxis and prostaglandin F 2α caused only slight constriction at high doses and histamine was not active. 3 Bradykinin was less active in the rat than in the guinea‐pig and its effects were not antagonized by anti‐inflammatory analgesic drugs. 4 β‐Adrenoceptor blockade potentiated the activity of bradykinin but not that of 5‐hydroxytryptamine or acetylcholine. 5 Dexamethasone reduced the activity of bradykinin but not that of 5‐hydroxytryptamine or acetylcholine. 6 Sensitization with Nippostrongylus brasiliensis did not increase the sensitivity of the rat lung to the effects of mediators.