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ACTIONS OF PROSTAGLANDIN E 2 ON MYOCARDIAL MECHANICS, CORONARY VASCULAR RESISTANCE AND OXYGEN CONSUMPTION IN THE GUINEA‐PIG ISOLATED HEART PREPARATION
Author(s) -
KREBS R.,
SCHRÖR K.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb06944.x
Subject(s) - reserpine , prostaglandin e2 , guinea pig , prostaglandin , chemistry , medicine , vascular resistance , endocrinology , prostaglandin e , oxygen , endogeny , blood pressure , organic chemistry
1 In isolated, electrically driven (3 Hz) hearts of guinea‐pigs the action of prostaglandin E 2 on left ventricular pressure (LVP), oxygen consumption ( Qo 2 ) and coronary vascular resistance (CVR) was studied by establishing cumulative concentration‐response curves. The hearts were perfused at a constant flow (10 ml/min) with Tyrode solution (Ca ++ 1.8 mM) at 32° C. 2 Under control conditions prostaglandin E 2 (2.86 × 10 −11 − 1.43 × 10 −7 M) decreased LVP, Q o 2 and CVR in a concentration‐dependent manner by maximally 27, 18 and 38%, respectively ( P < 0.05). 3 After reserpine pretreatment there were lower initial values for all parameters measured. The effect of prostaglandin E 2 on LVP and Q o 2 was abolished, but CVR was further diminished, depending on the concentration. 4 The results seem to support the hypothesis of an interaction of prostaglandin E 2 with endogenous catecholamines as far as the effects on LVP and Q o 2 are concerned. In contrast, prostaglandin E 2 seems to have a direct action on CVR, which is independent of the presence of catecholamines.