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BEHAVIOURAL CHANGES INDUCED IN CONSCIOUS MICE BY INTRACEREBROVENTRICULAR INJECTION OF CATECHOLAMINES, ACETYLCHOLINE AND 5‐HYDROXYTRYPTAMINE
Author(s) -
HERMAN Z.S.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb06938.x
Subject(s) - pimozide , acetylcholine , phenoxybenzamine , dopamine , methysergide , atropine , medicine , endocrinology , chemistry , propranolol , ventricle , locomotor activity , physostigmine , pharmacology , serotonin , haloperidol , receptor
1 A simple method of injecting soluble substances into the lateral ventricle of the brain of the conscious mouse is described. 2 The effect of various doses of noradrenaline, dopamine, acetylcholine, 5‐hydroxytryptamine given into the right lateral brain ventricle were tested on locomotor and exploratory activities of mice. 3 Noradrenaline in a dose of 0.1 μg increased locomotor activity. This effect was prevented by phenoxybenzamine but not by propranolol. 4 Higher doses of noradrenaline (1 or 10 μg) decreased locomotor and exploratory activities. Propranolol but not phenoxybenzamine abolished these effects. 5 Dopamine (0.1 or 1 μg) increased locomotor activity. The higher doses also induced tremor. 6 The highest dose of dopamine tested (10 μg) elicited stereotypical behaviour. 7 All the behavioural phenomena induced by 0.1 μg and 10 μg of dopamine were blocked by pimozide. 8 Acetylcholine (1 and 10 μg) and 5‐hydroxytryptamine (1 μg) inhibited locomotor and exploratory activity. 9 The effects of 1 and 10 μg of acetylcholine were abolished by atropine (5 mg/kg i.p.). Methysergide (5 mg/kg i.p.) had no influence on the effects of 5‐hydroxytryptamine (1 μg).