Premium
THE EFFECTS OF PROSTAGLANDINS ON GUINEA‐PIG ISOLATED INTESTINE AND THEIR POSSIBLE CONTRIBUTION TO MUSCLE ACTIVITY AND TONE
Author(s) -
BENNETT A.,
ELEY K.G.,
STOCKLEY HELEN L.
Publication year - 1975
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1975.tb06929.x
Subject(s) - guinea pig , contraction (grammar) , prostaglandin , endocrinology , medicine , muscle contraction , muscle tone , ileum , cholinergic , circular muscle , acetylcholine , excitatory postsynaptic potential , biology , prostaglandin e , chemistry , anatomy , smooth muscle , inhibitory postsynaptic potential , neuroscience
1 Prostaglandins F 1α and F 2α caused contraction of the longitudinal muscle of both guinea‐pig isolated ileum and colon, apparently by acting directly on the muscle and on cholinergic nerves. They had little effect on ileal circular muscle. 2 Prostaglandins E 1 and E 2 caused contraction of the longitudinal muscle of guinea‐pig isolated colon, apparently by acting directly on the muscle and on excitatory nerves which are non‐cholinergic. Prostaglandin E 1 seems more effective than E 2 in stimulating these nerves. 3 It seems likely that prostaglandin release in vitro maintains the tone of the longitudinal muscle of guinea‐pig colon, whereas release of a prostaglandin E compound inhibits circular muscle tone.