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EFFECT OF TEMPERATURE ON CHANGES, INDUCED BY OESTRUS, in α‐ AND β‐ADRENOCEPTOR ACTIVITIES OF THE RAT UTERUS
Author(s) -
BUTTERWORTH K.R.,
JARMAN D.A.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb10685.x
Subject(s) - phenylephrine , isoprenaline , estrous cycle , endocrinology , medicine , uterus , contraction (grammar) , chemistry , uterine contraction , epinephrine , adrenergic , adrenergic receptor , biology , receptor , stimulation , blood pressure
The α‐ and β‐adrenoceptor activities of the isolated rat uterus during the oestrous cycle were influenced greatly by temperature changes. During dioestrus, lowering the bath temperature to 25° C from 40° C increased two‐fold the inhibition produced by (–)‐adrenaline, (–)‐noradrenaline, (–)‐phenylephrine and (–)‐isoprenaline. During oestrus adrenaline, noradrenaline and phenylephrine produced biphasic responses of contraction followed by inhibition at 40° C and isoprenaline produced only inhibition. At 25° C the contractile α‐responses either were abolished (phenylephrine) or greatly reduced (adrenaline and noradrenaline), while the inhibitory β‐effects of all four amines were increased.