Premium
TRYPTAMINE RECEPTORS IN RAT PULMONARY ARTERY
Author(s) -
BAKHLE Y.S.,
SMITH T.W.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb10684.x
Subject(s) - methysergide , receptor , serotonin , 5 ht receptor , chemistry , tryptamine , endocrinology , morphine , perfusion , pulmonary artery , medicine , pharmacology
Tryptamine and 5‐hydroxytryptamine (5‐HT) are equipotent in contracting spiral strips of rat isolated pulmonary artery, in doses between 5 and 20 μg. These 5‐HT receptors are blocked by low concentrations (c. 10 −9 M) of both methysergide and morphine. In rat isolated lung perfused via the pulmonary circulation, 5‐HT caused increases in perfusion pressure which were also antagonized by methysergide and by morphine. These vascular 5‐HT receptors cannot therefore be classified as M or D receptors and, furthermore, are different from those 5‐HT receptors mediating release of spasmogens from rat isolated lungs.