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SENSITIZATION OF NORADRENALINE RESPONSES BY INHIBITORS OF EXTRANEURONAL UPTAKE IN A CORONARY ARTERY PREPARATION
Author(s) -
KALSNER S.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb10682.x
Subject(s) - sensitization , medicine , artery , endocrinology , chemistry , pharmacology , cardiology , immunology
Inhibition of neuronal uptake with cocaine had no significant effect on the dose‐response curve to noradrenaline in strips of beef coronary artery. However, responses were enhanced about 3‐fold by 17β‐oestradiol and the haloalkylamine GD‐131, two known inhibitors of extraneuronal uptake.