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INVESTIGATIONS ON THE MODE OF ACTION OF ERGOTAMINE IN THE ISOLATED FEMORAL VEIN OF THE DOG
Author(s) -
MÜLLERSCHWEINITZER E.,
STÜRMER E.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb10680.x
Subject(s) - ergotamine , femoral vein , medicine , popliteal vein , action (physics) , mode of action , anesthesia , anatomy , surgery , chemistry , migraine , thrombosis , deep vein , biochemistry , physics , quantum mechanics
1 Experiments on spiral strips cut from the femoral vein of dogs suspended in Krebs‐Henseleit solution were carried out. 2 Ergotamine caused stimulation in concentrations about 350 times lower than noradrenaline (ED 50 of ergotamine = 2.2 × 10 −9 m ; ED 50 of noradrenaline = 7.6 × 10 −7 M), but the maximal responses to ergotamine were only about one third those to noradrenaline. 3 The pA 2 value of ergotamine against noradrenaline was 8.8. 4 The effects of ergotamine can be blocked by prior administration of phentolamine. The pA 2 value for phentolamine against ergotamine was 6.8 and the pA 2 value for phentolamine against noradrenaline was 7.5. 5 It is concluded that the stimulant action of ergotamine on smooth vascular muscle probably is mediated mainly via α‐adrenoceptors.