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SPECIFIC SUPERSENSITIVITY OF SMOOTH MUSCLE TO ANGIOTENSIN II AFTER NEPHRECTOMY
Author(s) -
MEYER P.,
PAPADIMITRIOU A.,
WORCEL M.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb10679.x
Subject(s) - nephrectomy , carbachol , angiotensin ii , renin–angiotensin system , endocrinology , medicine , angiotensin receptor , chemistry , kidney , receptor , blood pressure
1 The dose‐response curves for angiotensin, 5‐hydroxytryptamine and carbachol were obtained on rat uterus and colon excised 24 h after a bilateral nephrectomy or a sham operation. 2 There was a shift to the left in the dose‐response curves to angiotensin of organs from nephrectomized animals. Dose‐response curves to 5‐hydroxytryptamine and carbachol were not affected by nephrectomy. 3 The interaction of the two competitive antagonists (1‐Asn, 5‐Ileu, 8‐Ala)‐angiotensin II and (1‐Asn, 5‐Ileu, 8‐Ileu)‐angiotensin II with angiotensin II receptors was tested in control and nephrectomized organs. There was a decrease of the K I values in colon muscle after nephrectomy. 4 In conclusion, nephrectomy produces a specific supersensitivity to angiotensin that seems to be due to a change in the structure of angiotensin receptors, at least in colon smooth muscle. This increase in sensitivity may be the result of the elimination of a tropic factor that acts on angiotensin receptor sites.