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SUPERSENSITIVITY TO ISOPRENALINE INDUCED IN RATS BY PROLONGED ISOLATION
Author(s) -
SPEISER ZIPORA,
WEINSTOCK MARTA
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb09730.x
Subject(s) - isoprenaline , propranolol , heart rate , medicine , endocrinology , blood pressure , weaning , stimulation
1 The effect of isoprenaline on diastolic blood pressure and heart rate was determined in anaesthetized male rats which had been housed individually for 6–8 weeks after weaning, and compared with its effect in group‐housed litter‐mate controls. 2 Isoprenaline caused a significantly greater fall in diastolic pressure in isolated rats and a greater increase in heart rate. 3 Low doses of noradrenaline (5–10 ng) caused vasodepressor responses in isolated, but not in group‐housed rats. 4 The pressor response to noradrenaline, which was smaller in isolated rats, was increased to the level of group‐housed controls by (±)‐propranolol. 5 Prolonged isolation of rats may bring about an increase in sensitivity of β‐adrenoceptors to isoprenaline and noradrenaline.