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ERGOMETRINE AND APOMORPHINE AS SELECTIVE ANTAGONISTS OF DOPAMINE IN THE CANINE RENAL VASCULATURE
Author(s) -
BELL C.,
CONWAY E.L.,
LANG W.J.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb09728.x
Subject(s) - apomorphine , ergometrine , dopamine , dilator , pimozide , dopamine receptor , medicine , endocrinology , pharmacology , anesthesia , chemistry , dopaminergic , haloperidol
1 Increases in renal blood flow were produced by intra‐arterial injections of dopamine (5–50 μg) in anaesthetized dogs pretreated with α‐ and β‐adrenoceptor antagonists. 2 Intra‐arterial administration of ergometrine (0.5 mg) or apomorphine (1 mg) produced a depression of the renal dilator responses to dopamine, without affecting renal dilatations in response to intra‐arterial acetylcholine (0.1–1 μg) or histamine (2–50 μg). 3 The depression of dopamine responses lasted 10–15 min, and was greater with ergometrine than with apomorphine. 4 It is concluded that both ergometrine and apomorphine can be used as specific blocking agents at vascular dopamine receptors. Ergometrine is the preferred drug for this purpose.