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CHANGES IN PLASMA KININOGEN LEVELS INDUCED BY CELLULOSE SULPHATE DURING PREGNANCY IN THE RAT
Author(s) -
McCORMICK J.T.,
SENIOR JUDITH,
WHALLEY E.T.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb09721.x
Subject(s) - kininogen , cellulose , pregnancy , chemistry , endocrinology , medicine , biochemistry , biology , bradykinin , receptor , genetics
1 Cellulose sulphate (1 mg/kg) produced a 30–40% depletion of plasma kininogen in rats. 2 The time course of repletion of kininogen in the plasma was compared in rats in the oestrous and dioestrous stages of the cycle and in 22 day pregnant animals. A partial repletion occurred, 3 h after the cellulose sulphate injection, which was followed by a secondary fall in plasma kininogen. Plasma kininogen values were back to control levels 10 h after the treatment in all groups. 3 Treatment of rats from days 19–22 of pregnancy with cellulose sulphate resulted in 40% depletion of plasma kininogen and in prolongation of pre‐parturition behaviour. 4 It is suggested that the increase which normally occurs in plasma kininogen levels towards the end of pregnancy in the rat may play a role in the process of parturition.