Premium
THE EFFECT OF NERVE STIMULATION ON THE AXONAL TRANSPORT OF NORADRENALINE AND DOPAMINE‐β‐HYDROXYLASE
Author(s) -
KEEN P.,
McLEAN W.G.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb09720.x
Subject(s) - stimulation , dopamine , spinal cord , sciatic nerve , axoplasmic transport , sympathetic nervous system , central nervous system , chemistry , neuroscience , medicine , endocrinology , biology , blood pressure
1 A method for stimulating the lumbar sympathetic outflow from the spinal cord of the rat is described which does not require artificial respiration of the animal. 2 In some, but not all experiments continuous stimulation at 2 Hz or intermittently at 10 Hz accelerated the rate at which noradrenaline and dopamine‐β‐hydroxylase accumulated central to a ligature on the sciatic nerve by approximately 40%. 3 It is concluded that, although nervous activity is not necessary for axonal transport of transmitter granules in sympathetic neurones, intense nervous activity may accelerate the rate of granule transport.