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EVIDENCE FOR INVOLVEMENT OF 5‐HYDROXYTRYPTAMINE IN THE ACTIONS OF AMPHETAMINE
Author(s) -
BREESE G.R.,
COOPER B.R.,
MUELLER R.A.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb09714.x
Subject(s) - amphetamine , pargyline , endocrinology , medicine , serotonin , dextroamphetamine , 5 hydroxytryptophan , pharmacology , tryptophan hydroxylase , tyrosine hydroxylase , chemistry , dopamine , serotonergic , receptor
1 Pargyline treatment, 1 h before (+)‐amphetamine (1 mg/kg), reduced amphetamine‐stimulated motor activity. This inhibition was reversed in animals pretreated with p ‐chlorophenylalanine (PCPA). 2 Following treatment with PCPA or 5,6‐dihydroxytryptamine (5,6‐DHT), amphetamine‐induced locomotor activity was significantly potentiated. The increased response to amphetamine in PCPA‐treated rats was reversed in animals pretreated with 5‐hydroxytryptophan. 3 The inhibition of amphetamine‐stimulated locomotor activity by treatment with 6‐hydroxydopamine was not reversed by PCPA treatment. 4 Stereotypies produced by amphetamine were not found to be altered by depletion of 5‐hydroxytryptamine. 5 Induction of adrenal tyrosine hydroxylase activity produced by chronic amphetamine administration was significantly potentiated by PCPA, emphasizing the involvement of a 5‐hydroxytryptamine inhibitory system in more than one action of amphetamine.