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GASTRIN RELEASE BY BOMBESIN IN THE DOG
Author(s) -
BERTACCINI G.,
ERSPAMER V.,
MELCHIORRI P.,
SOPRANZI N.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb09703.x
Subject(s) - bombesin , gastrin , chemistry , endocrinology , medicine , neuropeptide , receptor , secretion
1 The intravenous infusion of bombesin produced in intact dogs and, more strikingly in dogs provided with gastric fistulae a sharp increase in plasma levels of immunoreactive gastrin and at the same time a stimulation of gastric acid secretion. Gastrin response was correlated with the dose of bombesin from approximately 0.1 μg kg −1 h −1 (threshold) to 1 μg kg −1 h −1 (maximum gastrin release). 2 Atropine and metiamide reduced or inhibited gastric acid secretion stimulated by bombesin, but did not affect the rise in gastrin levels. 3 Acidification of the whole stomach or of a perfused antral pouch caused a reduced or delayed response to bombesin. However, the inhibitory effect of acidification could be surmounted by prolonging the duration of bombesin infusion. 4 Antrectomy greatly reduced the rise in gastrin levels and the increase in acid gastric secretion produced by bombesin, but left unaffected the gastric secretagogue effect of pentagastrin. 5 It is concluded that bombesin is a potent releaser of gastrin from the antral mucosa. 6 The possible influence of the renal effects evoked by bombesin in the dog on the gastrin response to the polypeptide is discussed.