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EFFECT OF SYMPATHOMIMETIC AMINES ON THE HISTAMINE FORMING CAPACITY OF HUMAN LEUCOCYTES
Author(s) -
ASSEM E.S.K.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb09702.x
Subject(s) - phentolamine , histamine , isoprenaline , potency , phenylephrine , stimulation , propranolol , chemistry , endocrinology , medicine , beta (programming language) , in vitro , pharmacology , alpha (finance) , biology , biochemistry , blood pressure , construct validity , nursing , patient satisfaction , computer science , programming language
1 The effects of α‐ and β‐adrenoceptor stimulants on the histamine‐forming capacity (HFC) of human isolated leucocytes have been studied, in vitro . 2 It was confirmed that antigen significantly stimulates the HFC of human leucocytes. 3 β‐Adrenoceptor stimulants, such as isoprenaline and salbutamol (10 −6 ‐10 −3 m ) significantly inhibited the HFC of human leucocytes in the presence and absence of antigen. At concentrations lower than 10 −6 m , this effect was not observed. In general the degree of inhibition of HFC by β‐adrenoceptor stimulants followed their potency as β‐adrenoceptor stimulants. 4 α‐Adrenoceptor stimulants significantly stimulated leucocyte HFC; noradrenaline within a limited concentration of 10 −6 m , while stimulation was seen consistently with phenylephrine at concentrations of 10 −7 ‐10 −4 m . Adrenaline, which stimulates both α‐ and β‐adrenoceptors, produced small inhibition, no effect, or a degree of stimulation. 5 Phentolamine, an α‐adrenoceptor blocking agent, produced an effect opposite to that of the α‐adrenoceptor stimulants, i.e. a significant inhibition of the HFC of human isolated leucocytes.