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ANTAGONISM OF INHIBITORY AMINO ACID ACTION BY TUBOCURARINE
Author(s) -
CURTIS D.R.,
GAME C.J.A.,
McCULLOCH R.M.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb09693.x
Subject(s) - antagonism , inhibitory postsynaptic potential , d tubocurarine , pharmacology , chemistry , neuroscience , biology , biochemistry , receptor
A comparison has been made of the antagonism by microelectrophoretically administered (+)‐tubocurarine, bicuculline methochloride and strychnine of the inhibition of spinal interneurones and Renshaw cells in the cat by glycine and γ‐aminobutyric acid. The results indicate that (+)‐tubocurarine would be of little use in assessing which of these amino acids was the transmitter at central inhibitory synapses.