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EFFECTS OF DIPYRIDAMOLE ON NEUROGENIC AND NON‐NEUROGENIC DILATOR RESPONSES OF ARTERIAL SMOOTH MUSCLE
Author(s) -
BELL C.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb09681.x
Subject(s) - dilator , cholinergic , acetylcholine , dipyridamole , endocrinology , medicine , stimulation , adenosine , inhibitory postsynaptic potential
1 In the isolated, perfused parametrial artery of the guinea‐pig dipyridamole (10–100 ng/ml) potentiated dilator responses to adenosine 5′‐triphosphate (ATP), glyceryl trinitrate and non‐cholinergic, non‐adrenergic inhibitory nerve stimulation to similar extents. In contrast dilator responses to acetylcholine were generally unaffected or reduced. 2 These results support previous electro‐physiological evidence that in this preparation cholinergic vasodilatation is mediated by a cellular mechanism different from that involved in the response to non‐cholinergic dilator nervous activation. 3 The results also suggest that potentiation of a neurally‐mediated inhibitory response of smooth muscle by dipyridamole does not necessarily implicate ATP as the transmitter involved in this response.