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PULMONARY MECHANICAL EFFECTS OF EXPERIMENTAL LUNG EMBOLISM AND THEIR MODIFICATION BY BRONCHODILATOR DRUGS IN THE GUINEA‐PIG
Author(s) -
DALY M.J.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb09679.x
Subject(s) - bronchodilator , guinea pig , bronchodilator agents , medicine , lung , pulmonary embolism , pharmacology , anesthesia , asthma
In the anaesthetized guinea‐pig micro‐embolism induced by barium sulphate causes marked increases in pulmonary resistance and decreases in pulmonary compliance. Bronchodilator drugs prevent these changes with salbutamol showing much greater activity on pulmonary resistance changes than compliance changes. The results are discussed with regard to the site of action in the respiratory tree and potential clinical use.