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EFFECTS OF CATECHOLAMINES ON THERMOREGULATION IN PIGEONS
Author(s) -
CHAWLA NARESH,
JOHRI M.B.L.,
SAXENA P.N.,
SINGHAL K.C.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb09667.x
Subject(s) - thermoregulation , norepinephrine , neuroscience , biology , endocrinology , dopamine
1 In unanaesthetized pigeons, kept at room temperature (20–23°C) the effects on cloacal temperature were examined of catecholamines, phenoxybenzamine and propranolol, injected into the cerebral ventricles. 2 Noradrenaline, adrenaline, dopamine and isoprenaline caused a fall in cloacal temperature. 3 Phenoxybenzamine produced a long‐lasting small rise in cloacal temperature. This rise is attributed to removal of the hypothermic effect of noradrenaline released continuously from adrenergic neurones ending in the anterior hypothalamus. Propranolol produced a slight fall in cloacal temperature. 4 The hypothermic effects of noradrenaline, adrenaline and dopamine were prevented by phenoxybenzamine but not by propranolol. They are therefore attributed to activation of α‐adrenoceptors. 5 The hypothermic effect of isoprenaline was not prevented by either phenoxybenzamine or propranolol. The effect can therefore not be attributed to activation of either α or β‐adrenoceptors. Propranolol actually accentuated the isoprenaline‐induced hypothermia.