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EFFECT OF P‐CHLOROPHENYLALANINE ON BRAIN MONOAMINES AND BEHAVIOUR DURING ETHANOL WITHDRAWAL IN MICE
Author(s) -
GRIFFITHS P.J.,
LITTLETON J.M.,
ORTIZ A.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb09662.x
Subject(s) - ethanol , monoamine neurotransmitter , serotonin , medicine , endocrinology , norepinephrine , kindling , chemistry , psychology , pharmacology , dopamine , stimulation , biochemistry , receptor
The administration of p ‐chlorophenylalanine to mice prevents the rise in brain 5‐hydroxytryptamine concentration associated with ethanol withdrawal but does not affect the increase in brain catecholamines which occurs at the same time. The locomotor excitement, piloerection, tremor and handling convulsions which occur during ethanol withdrawal were not affected. These results suggest that the increase in brain 5‐hydroxytryptamine which occurs in ethanol withdrawal is a consequence of increased 5‐hydroxytryptamine synthesis and that it is probably not involved in the above behavioural changes of ethanol withdrawal.