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ON THE SIMULTANEOUS ACTION OF TWO COMPETITIVE ANTAGONISTS
Author(s) -
GINSBORG B.L.,
STEPHENSON R.P.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb09659.x
Subject(s) - antagonist , agonist , competitive antagonist , methiodide , chemistry , dissociation constant , agonist antagonist , pharmacology , stereochemistry , biology , receptor , biochemistry
1 A hypothesis is outlined predicting the conditions in which the addition of a second competitive antagonist will increase rather than reduce the response to an agonist. 2 Experiments were performed with the guinea‐pig ileum as the test tissue, hexyltrimethyl ammonium as the agonist, benzilyltropine methiodide as the ‘slow’ antagonist and pentyltriethyl ammonium as the ‘fast’ antagonist. 3 The results are consistent with the hypothesis, if the affinity constant for hexyltrimethyl ammonium is between 2.7 and 3.7 × 10 4 m −1 , if the dissociation time constant for the slow antagonist is greater than 10 min and if that for the fast antagonist is less than 10 seconds.