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MANGANESE IONS AND SYNAPTIC TRANSMISSION IN THE SUPERIOR CERVICAL GANGLION OF THE CAT
Author(s) -
KOSTIAL KRISTA,
LANDEKA M.,
ŠLAT B.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb09652.x
Subject(s) - manganese , acetylcholine , superior cervical ganglion , neurotransmission , ganglion , chemistry , biophysics , sympathetic ganglion , anatomy , biology , endocrinology , biochemistry , receptor , organic chemistry
1 In the perfused superior cervical ganglion of the cat manganese ions (2.7 − 4.6 m m ) caused a block of synaptic transmission and reduced the output of acetylcholine. 2 Calcium ions (8.4–10.5 m m ) relieved the synaptic block produced by manganese and partially restored the acetylcholine output. 3 The presence of manganese also reduced the sensitivity of ganglion cells to injected acetylcholine. 4 Both effects of manganese were completely reversible.