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CARDIOVASCULAR ACTIONS OF PROSTAGLANDIN C IN THE CAT AND DOG
Author(s) -
JONES R.L.,
KANE KATHLEEN A.,
UNGAR A.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb09642.x
Subject(s) - blood pressure , inotrope , medicine , heart rate , cardiology , stroke volume , prostaglandin , diastole , ventricular pressure
1 Prostaglandin C 2 causes a prolonged fall in arterial blood pressure in the cat. 2 At constant heart rate this fall in arterial pressure is accompanied by falls in stroke volume, left ventricular end diastolic pressure, and left ventricular d P /d t max . 3 If mean aortic pressure and left ventricular end diastolic pressure are held constant as well as heart rate, prostaglandins C 2 and E 2 do not affect d P /d t max in the cat. 4 In the dog, under similarly controlled conditions, prostaglandins C 2 and E 2 raise d P /d t max . 5 We conclude that prostaglandins E 2 and C 2 have no direct inotropic action in the cat, but both have a direct positive inotropic action in the dog.