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EFFECTS OF CATECHOLAMINE SYNTHESIS INHIBITION ON ETHANOL‐INDUCED WITHDRAWAL SYMPTOMS IN MICE
Author(s) -
BLUM K.,
WALLACE J.E.
Publication year - 1974
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1974.tb09640.x
Subject(s) - catecholamine , ethanol , long term potentiation , convulsion , dopamine , chemistry , endocrinology , medicine , pharmacology , tyrosine hydroxylase , biochemistry , receptor , epilepsy , psychiatry
α‐Methyl‐ p ‐tyrosine, a catecholamine synthesis inhibitor, was studied to determine its effects against ethanol‐induced withdrawal symptoms in mice. Significant ( P < 0.001) potentiation of the withdrawal convulsion score induced by ethanol vapour exposure for three days was observed in mice. The synergistic effect was not due to alteration of ethanol metabolism. These results indicate that reductions in catecholamines (dopamine and noradrenaline) augment seizure activity induced by subchronic exposure to ethanol.